Deepak Ranglani†, Shubham Agiwal†, Namdev More†, Rohit Parkale†, Vaibhav Shitole†, Aishwarya Rajaram Hiray†, Govinda Kapusetti*
Department of Medical Devices National Institute of Pharmaceutical Education and Research, Ahmedabad
Authors having equal contributions.
Received 14 June 2020, Accepted 16 December 2020, Available Online 18 January 2021.
- Tympanic membrane; auditory canal; tissue engineering; biomaterials; cells; growth factors; stem cells
The impairment in the Tympanic Membrane (TM) and the External Auditory Canal (EAC) results in otitis media, tympanos-clerosis, and perforations. The resulting reverberation of these pathologies is the loss of hearing, which eventually requires surgical treatment. The gold standard for the surgical procedures, autologous temporalis fascia, is reported with limited success. In recent times the biomaterial substitutes for this very purpose have carried off tremendous interest. The current review explicitly focuses on the last 10 years reports describing TM and EAC regeneration by biomaterial intervention. This review also provides an intelligible insight into various fabrication techniques for grafting to mimic TM-collagen’s radial and circular patterns. In the end, we have reached the terms by highlighting the future of the biomaterials in contrast to the current challenges in TM and EAC regeneration. Overall, the review will be a better source for developing futuristic biomaterials for the discussed problem.
- © 2021 The Authors. Published by Atlantis Press B.V.
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).