Accepted 9 April 2021
Available Online 21 April 2021
- PVP-induced synthesis
pH-controlled drug release
Traditional cancer therapy faces the main fail due to the effect of drug burst release, hindering the long-term therapeutic efficacy. SiO2 nano systems possess high-capacity and pH-controlled release for anti-cancer drug, improving the curative efficacy in cancer treatment. Thus, we designed a novel method to construct Silica Nanoparticles (SiO2 NPs) with diameters of ca. 150 nm by adding different amounts of PVP. The maximum drug-loading of the synthesized SiO2 NPs is about 30 μg·mg−1, exhibiting excellent pH-responsive drug releasing ability in the simulated physiological environment. Meanwhile, the prepared SiO2 NPs also harbor well biocompatibility, which are suitable for potential cancer therapy in clinic.
- © 2021 The Authors. Published by Atlantis Press B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite This Article
TY - JOUR AU - Wei Yang AU - Zheng Yang PY - 2021 DA - 2021/04/21 TI - PVP-Induced Synthesis of Silica Nanoparticles with Tailored Size for pH-Controlled Drug Release JO - Materials Highlights SP - 52 EP - 57 VL - 2 IS - 3 SN - 2666-4933 UR - https://doi.org/10.2991/mathi.k.210414.001 DO - https://doi.org/10.2991/mathi.k.210414.001 ID - Yang2021 ER -